What to do when valtrex stops working

Here’s an all too common story from a cold sore sufferer for whom pharmaceutical cold sore treatments have failed miserably:

“I’m on 1 gram of Valcyclovir (Valtrex) a day because I was getting cold sores so often in the beginning of this year. How can I still be getting outbreaks? Has this happened to anyone else? I take 5000mg of Lysine a day (up to 10,000mg if I feel any tingles or itch), my 1 gram Valtrex (up to 2g twice a day 12 hours a part if I feel any tingles), I stay away from high arginine foods, low caffeine, coffee only once a week, no nuts, no chocolate. What am I doing wrong?”

One gram of valtrex… 5 grams of lysine per day… avoids so-called ‘food triggers’…

Pretty sure that constitutes everything, including the kitchen sink.

And she’s still breaking out constantly.

That’s gotta suck hard.

I mean, she’s doing basically everything that the internet at large tells her to do to prevent cold sores from coming back, but it’s not working. At all.

Plus, it’s not just random internet advice that’s failing her either.

It’s her (presumably well-paid) doctor as well.

He’s the one who prescribed daily valtrex (despite the laundry list of potential side effects that accompany prescription anti-virals, as we talked about the other day). And I have no idea if her doctor is aware that it’s not working for her, but I’d guess there’s a 90% chance that said doctor has no other solution for her beyond writing another prescription.

It’s easy to feel like you’re out of options in a situation like this.

But here’s the thing.

When I look at everything she is doing to hopefully prevent her cold sores from coming back…

I’m not all that surprised it’s not working.


For the same reason I’ve been saying for years:

Prescription anti-virals… lysine supplements… avoiding argining in food… NONE of those actually prevent the herpes virus from reactivating and infecting your lips in the first place.

See, these treatment strategies interfere with the replication process of the virus, AFTER it’s infected the skin cells in your lips.

But they don’t stop the c-jun-N-terminal-kinase pathway from activating (which causes the herpes virus to wake up) and they don’t stop your lips from getting infected in the first place.

See the difference?

And here’s another thing.

There’s a growing body of scientific evidence showing that regularly taking man-made, pharmaceutical medications such as acetaminophen (i.e. Tylenol) can help create an environment in your body that promotes the activation of said c-jun-N-terminal-kinase pathway (and thus, reactivation of the herpes virus).

Do prescription anti-virals do the same thing?

No idea. There aren’t any studies that looked into this specifically (that I’m aware of).

But if I was a betting man?

I can only assume that they do, at least to some extent. Hey, pumping your body full of chemicals (which most pharmaceutical compounds are, make no mistake) on a daily basis inevitably leads to damaging metabolites your body has to work to flush out.

Now, I’m not saying that valtrex triggers more cold sores than it prevents.

That would be a silly thing to say.

What I’m saying is, I wouldn’t be surprised if it helps create a situation where viral reactivation is more likely. Creating a sort of ‘create the disease, sell the cure’ type situation.

Makes me wonder if this could be what’s causing this cold sore sufferer in particular to break out so often…

Anyway. That’s my $0.02.

If you want to learn how to stop cold sores from coming back WITHOUT relying on daily prescription pharmaceuticals or having to gag down 10 grams of lysine pills every day, take the Cold Sore Quiz at the link below:

Take the 60-Second Cold Sore Quiz Right Now

It’ll figure out why YOUR cold sores keep coming back, and show you how to finally put a stop to them.


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Chris "the Cold Sore Killer" Mueller